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Plos One : Genome Wide Association Study of Age at Menarche in the Japanese Population, Volume 8

By He, Chunyan

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Book Id: WPLBN0003949056
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Genome Wide Association Study of Age at Menarche in the Japanese Population, Volume 8  
Author: He, Chunyan
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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He, C. (n.d.). Plos One : Genome Wide Association Study of Age at Menarche in the Japanese Population, Volume 8. Retrieved from http://worldlibrary.in/


Description
Description : Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large-scale meta-analysis of genome-wide association studies using more than 15,000 Japanese female samples. Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.4961027 and an effect size of 0.089 (year). We also evaluated 33 SNPs that were previously reported to be associated with AAM in women of European ancestry. Among them, two SNPs rs4452860 and rs7028916 in TMEM38B indicated significant association with AAM in the same directions as reported in previous studies (P = 0.0013 with an effect size of 0.051) even after Bonferroni correction for the 33 SNPs. In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P,0.05). Our findings elucidated the impact of genetic variations on AAM in the Japanese population.

 

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